Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i>
نویسندگان
چکیده
The genus Claviceps (Clavicipitaceae) is noted for producing ergot alkaloids that cause ergotism. yanagawaensis, a parasite of Zoysia japonica (family: Poaceae), has been isolated in Japan. Bioactivity screening showed methanol extract from rice culture C. yanagawaensis was cytotoxic to cancer cells. In our search active substances, the new secalonic acid analogues (-)-5-epi-F-7 (1) and ergochrysin C (2) benzoic analogue, dimethyl bigutol (3), were along with known compounds 3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)benzoic (4) methyl veratrate (5). structures 1 - 3 elucidated by NMR, MS, circular dichroism spectroscopy. MTT assays 5 using cell lines (HepG2, HL60, HT29, PANC-1, T98G) 4 exhibited cytotoxicity against
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ژورنال
عنوان ژورنال: Advances in microbiology
سال: 2022
ISSN: ['2165-3402', '2165-3410']
DOI: https://doi.org/10.4236/aim.2022.1212045